| | Key Topics | |-------------|----------------| | Biopharmaceutics | Drug absorption, transport mechanisms, dissolution, pH-partition theory, pre-systemic metabolism | | Pharmacokinetics | Compartment modeling (one and two compartments), non-compartmental analysis | | Kinetic Parameters | Half-life (t½), clearance (Cl), volume of distribution (Vd), AUC, MRT | | Dosage Regimen Design | Loading dose, maintenance dose, intermittent intravenous infusion, multiple dosing | | Bioavailability | Absolute/relative bioavailability, bioequivalence, in-vitro-in-vivo correlation (IVIVC) | | Non-linear Pharmacokinetics | Michaelis-Menten kinetics, causes of non-linearity (saturable absorption, metabolism) |
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